Invited Seminar Mayo Clinic, Rochester, USA
February 5th, 2015
Functional UltraSound (fUS) imaging of brain activity: from rodents to humans.
Brain imaging technologies are crucial for understanding the relationships between specific areas of the brain and their function in normal brain but also helping to locate the areas of the brain that are affected by diseases or neurological disorders in pathological brain.
Functional ultrasound (fUS) imaging is an innovative imaging technology based on Doppler ultrasound. fUS imaging can record brain activity at unprecedented spatio-temporal resolution (up to 10um pixel size and 20ms) and in real-time. fUS combines high frequency imaging (20-30 MHz) and high frame rate imaging (10-20 kHz) to track hemodynamic variations in single microvessels and in the entire depth of the rodents brain which is difficult to achieve with others imaging modalities. The benefits of functional ultrasound imaging include excellent safety record, portability and affordable price in comparison with MRI or PET.
I will present the advantages of functional ultrasound imaging in the better understanding of the neurovascular coupling as well as in different diseases such as stroke, migraine in anesthetized and head fixed rodents. I will also present our recent data on freely moving fUS imaging in rats during various behavioural states such as quiet rest, after whisker or visual stimulations, and in a food-reinforced operant task. Here we demonstrated that fUS imaging can efficiently decode brain activity in real-time.
On the strength of these results, I will present preliminary data from our first clinical trial in patients having a pharmaco-resistant epilepsy: « ULtrasound imaging or surgical treatment of cortical dYSplasia »
Thanks again to Dr. Kendall Lee for the invitation.